AKR1C2 Antikörper (AA 1-123)

Produktnummer ABIN5692785

Produktdetails anti-AKR1C2 Antikörper

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Bindungsspezifität: AA 1-123

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKR1C2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Aldo-keto reductase family 1 member C1/C2(AKR1C1/C2) detection. Tested with WB in Human,Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human AKR1C1/C2 recombinant protein (Position: M1-K123).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5 μg/mL, Human, Rat

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.

Details zu AKR1C2

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Andere Bezeichnung: AKR1C2 (AKR1C2 Produkte)

Hintergrund:

Synonyms: Aldo-keto reductase family 1 member C2,1.-.-.-,3-alpha-HSD3,Chlordecone reductase homolog HAKRD,Dihydrodiol dehydrogenase 2,DD-2,DD2,Dihydrodiol dehydrogenase/bile acid-binding protein,DD/BABP,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,1.3.1.20 ,Type III 3-alpha-hydroxysteroid dehydrogenase,1.1.1.357 ,AKR1C2,DDH2,

Tissue Specificity: Expressed in fetal testes. Expressed in fetal and adult adrenal glands. .

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. And this gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Molekulargewicht: 36735 MW

UniProt: P52895

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process