UVRAG Antikörper (AA 490-540)

Produktnummer ABIN5690316

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UVRAG in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für UVRAG Antikörper (AA 490-540) (ABIN5690316)

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UVRAG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-UVRAG Antikörper

Bindungsspezifität: AA 490-540

Spezifität: UVRAG antibody is human and mouse reactive.

Aufreinigung: UVRAG antibody is affinity chromatography purified via peptide column.

Immunogen: UVRAG antibody was raised against an 18 amino acid peptide near the carboxy terminus of human UVRAG.

The immunogen is located within amino acids 490 - 540 of UVRAG.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: UVRAG antibody can be used for detection of UVRAG by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: UVRAG antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: UVRAG antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Andere Bezeichnung: UVRAG

Hintergrund: The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1). UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2). UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5).

Molekulargewicht: Predicted: 77 kDa

Observed: 75 kDa

Gen-ID: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5