IQSEC1 Antikörper (AA 60-110)

Produktnummer ABIN5690018

Dieses Anti-IQSEC1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IQSEC1 in WB, ELISA, ICC und IF. Geeignet für Maus, Human und Ratte.

Kurzübersicht für IQSEC1 Antikörper (AA 60-110) (ABIN5690018)

Target: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IQSEC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-IQSEC1 Antikörper

Bindungsspezifität: AA 60-110

Spezifität: IQSEC1 antibody is human, mouse and rat reactive. At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is predicted to not cross-react with IQSEC2.

Aufreinigung: IQSEC1 antibody is affinity chromatography purified via peptide column.

Immunogen: IQSEC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human IQSEC1.

The immunogen is located within amino acids 60 - 110 of IQSEC1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IQSEC1 antibody can be used for detection of IQSEC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry at 2 μ,g/mL. For immunofluorescence start at 2 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IQSEC1 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: IQSEC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu IQSEC1

Target: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Andere Bezeichnung: IQSEC1

Hintergrund: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1). As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3). IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4).

Molekulargewicht: Predicted: 106 kDa

Observed: 103 kDa

Gen-ID: 9922

NCBI Accession: NP_055684

UniProt: Q6DN90