SNCA Antikörper (AA 127-135)

Produktnummer ABIN5689372

Der Kaninchen Polyklonal Anti-SNCA-Antikörper wurde für WB validiert. Er ist geeignet, SNCA in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für SNCA Antikörper (AA 127-135) (ABIN5689372)

Target: SNCA (Synuclein, alpha (SNCA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SNCA Antikörper

Bindungsspezifität: AA 127-135

Spezifität: This antibody detects endogenous level of total Synuclein protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: a-Synuclein (Ab-129) antibody was raised against a peptide sequence around aa.127~131 (M-P-S-E-E) derived from Human α,-Synuclein.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Andere Bezeichnung: a Synuclein

Hintergrund: SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95 % sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

Molekulargewicht: 18 kDa

Gen-ID: 6622

NCBI Accession: NP_000336

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity