JUP Antikörper (AA 726-730)

Produktnummer ABIN5689306

Der Kaninchen Polyklonal Anti-JUP-Antikörper wurde für WB validiert. Er ist geeignet, JUP in Proben von Human und Ratte zu detektieren.

Kurzübersicht für JUP Antikörper (AA 726-730) (ABIN5689306)

Target: JUP (Junction Plakoglobin (JUP))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JUP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-JUP Antikörper

Bindungsspezifität: AA 726-730

Spezifität: This antibody detects endogenous levels of total gamma-Catenin protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: gamma-Catenin antibody was raised in was raised against a peptide sequence around aa.726~730 (I-D-T-Y-S) derived from Human gamma-Catenin.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu JUP

Target: JUP (Junction Plakoglobin (JUP))

Andere Bezeichnung: gamma Catenin 

Hintergrund: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton

Molekulargewicht: 83 kDa

Gen-ID: 3728

NCBI Accession: NP_002221

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location