PKM1/2 (AA 36-40) Antikörper

Produktnummer ABIN5689255

Produktdetails

Target: PKM1/2

Bindungsspezifität: AA 36-40

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of total PKM1/2 protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: PKM1/2 antibody was raised against a peptide sequence around aa. 36~40 (D-S-P-P-I) derived from Human PKM1/2.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Antigendetails

Target: PKM1/2

Andere Bezeichnung: PKM1 / 2

Hintergrund: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Molekulargewicht: 60 kDa

Gen-ID: 5315

NCBI Accession: NP_872270

UniProt: P14618