AQP2 Antikörper (pSer261)

Produktnummer ABIN5688893

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-AQP2 Antikörper (ABIN5688893) detektiert spezifisch AQP2 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund, Rind (Kuh) und Huhn.

Kurzübersicht für AQP2 Antikörper (pSer261) (ABIN5688893)

Target: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AQP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-AQP2 Antikörper

Bindungsspezifität: pSer261

Aufreinigung: Affinity Purified

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser261 of rat aquaporin 2.

Anwendungsinformationen

Applikationshinweise: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with canine, bovine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Aquaporin 2 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Referenzen für anti-AQP2 Antikörper (ABIN5688893)

Sugito, Etriwati, Akmal, Rahmi, Delima, Muchlisin, Hasan: "Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure." in: TheScientificWorldJournal, Vol. 2021, pp. 8711286, (2022) (PubMed).

Details zu AQP2

Target: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Andere Bezeichnung: Aquaporin 2

Hintergrund: Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al., 2007).

Molekulargewicht: 29/37 kDa

Gen-ID: 25386

UniProt: P34080

Pathways: Response to Water Deprivation