Connexin Antikörper (C-Term)

Produktnummer ABIN5688865

Der Kaninchen Polyklonal anti-Connexin Antikörper wird verwendet zum Nachweis von Connexin in Proben von Huhn, Hund, Human, Maus, Ratte, Schaf, Xenopus laevis und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für Connexin Antikörper (C-Term) (ABIN5688865)

Target: Connexin

Reaktivität: Huhn, Hund, Human, Maus, Ratte, Schaf, Xenopus laevis, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Western Blotting (WB)

Produktdetails anti-Connexin Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Affinity Purified

Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.

Anwendungsinformationen

Applikationshinweise: The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Connexin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Details zu Connexin

Target: Connexin

Hintergrund: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).

Molekulargewicht: 43 kDa

Gen-ID: 24392

UniProt: P08050