Connexin Antikörper (C-Term)
Der Kaninchen Polyklonal Anti-Connexin-Antikörper wurde für WB validiert. Er ist geeignet, Connexin in Proben von Huhn, Hund, Human, Maus, Ratte, Schaf, Xenopus laevis und Zebrafisch (Danio rerio) zu detektieren.
Produktnummer ABIN5688865
Kurzübersicht für Connexin Antikörper (C-Term) (ABIN5688865)
Target
Connexin
Reaktivität
Huhn, Hund, Human, Maus, Ratte, Schaf, Xenopus laevis, Zebrafisch (Danio rerio)
Wirt
Kaninchen
Klonalität
Polyklonal
Applikation
Western Blotting (WB)
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Bindungsspezifität
- C-Term
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Aufreinigung
- Affinity Purified
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Immunogen
- Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
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Applikationshinweise
- The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Connexin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- Connexin
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Hintergrund
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
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Molekulargewicht
- 43 kDa
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Gen-ID
- 24392
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UniProt
- P08050
Target
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