Ubiquitin hydrolase 1 Antikörper

Produktnummer ABIN5688748

Der Maus Monoklonal anti-Ubiquitin hydrolase 1 Antikörper wird verwendet zum Nachweis von Ubiquitin hydrolase 1 in Proben von Human, Rind (Kuh), Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für Ubiquitin hydrolase 1 Antikörper (ABIN5688748)

Target: Ubiquitin hydrolase 1

Reaktivität: Human, Rind (Kuh), Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: MCA-BH7

Produktdetails

Spezifität: Specific for the ~24  kDa UCHL1 protein.

Aufreinigung: Total IgG fraction

Immunogen: Recombinant full length human UCHL1 purified from E. coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Informationen zur Lagerung: Ubiquitin Hydrolase 1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Antigendetails

Target: Ubiquitin hydrolase 1

Hintergrund: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.

Molekulargewicht: 24 kDa

Gen-ID: 7345

UniProt: P09936