THRA Antikörper (N-Term)

Produktnummer ABIN5688665

Dieses Anti-THRA-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von THRA in WB. Geeignet für Human, Maus, Ratte und Hund.

Kurzübersicht für THRA Antikörper (N-Term) (ABIN5688665)

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser THRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1718

Produktdetails anti-THRA Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Protein G purified

Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a1/a2-isotype.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with canine, mouse and rat based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Thyroid Hormone Receptor antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Details zu THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Andere Bezeichnung: Thyroid Hormone Receptor

Hintergrund: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Molekulargewicht: 50/58 kDa

Gen-ID: 7067

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development