Peripherin Antikörper

Produktnummer ABIN5687475

Dieser Huhn Polyklonal Antikörper detektiert spezifisch Peripherin in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Säugetier.

Kurzübersicht für Peripherin Antikörper (ABIN5687475)

Target: Peripherin (PRPH)

Reaktivität: Säugetier

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser Peripherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Peripherin Antikörper

Spezifität: Specific for the ~57  kDa peripherin protein.

Aufreinigung: Total IgY fraction

Immunogen: Recombinant rat peripherin expressed in and purified from E. coli.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Informationen zur Lagerung: Peripherin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Details zu Peripherin

Target: Peripherin (PRPH)

Andere Bezeichnung: Peripherin

Hintergrund: Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.

Molekulargewicht: 57 kDa

Gen-ID: 24688

UniProt: P21807