S1PR2 Antikörper (Internal Region)

Produktnummer ABIN568703

Produktdetails anti-S1PR2 Antikörper

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser S1PR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-NYTKETLETQ

Spezifität: Recognizes EDG-5 / S1P2.

Kreuzreaktivität (Details): Species reactivity (expected):Dog.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_004221.3. Genename: S1PR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-S1PR2 Antikörper (ABIN568703)

Song, Hou, Chen, Cheng, Lei, Cui, Sun, Wang, Fang: "Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome." in: Anesthesiology, Vol. 129, Issue 2, pp. 311-320, (2019) (PubMed).

Details zu S1PR2

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Andere Bezeichnung: EDG-5 / S1P2 (S1PR2 Produkte)

Synonyme: AGR16 antikoerper, EDG-5 antikoerper, EDG5 antikoerper, Gpcr13 antikoerper, H218 antikoerper, LPB2 antikoerper, S1P2 antikoerper, 1100001A16Rik antikoerper, Edg5 antikoerper, LPb2 antikoerper, GPCR18 antikoerper, snGPCR18 antikoerper, sphingosine-1-phosphate receptor 2 antikoerper, S1PR2 antikoerper, S1pr2 antikoerper

Hintergrund: The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: AGR16, EDG5, Endothelial differentiation G-protein coupled receptor 5, Gpcr13, H218, LPB2, S1P receptor 2, S1PR2, Sphingosine 1-phosphate receptor 2

Gen-ID: 9294

NCBI Accession: NP_004221

UniProt: O95136

Pathways: Synaptic Membrane