S1PR2 Antikörper (Internal Region)

Produktnummer ABIN568703

Es gibt 1 Publikation für dieses Produkt. Der Ziege Polyklonal anti-S1PR2 Antikörper wird verwendet zum Nachweis von S1PR2 in Proben von Human, Maus, Ratte und Hund. Er wurde validiert für WB und EIA.

Kurzübersicht für S1PR2 Antikörper (Internal Region) (ABIN568703)

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser S1PR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-S1PR2 Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-NYTKETLETQ

Spezifität: Recognizes EDG-5 / S1P2.

Kreuzreaktivität (Details): Species reactivity (expected):Dog.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_004221.3. Genename: S1PR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-S1PR2 Antikörper (ABIN568703)

Song, Hou, Chen, Cheng, Lei, Cui, Sun, Wang, Fang: "Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome." in: Anesthesiology, Vol. 129, Issue 2, pp. 311-320, (2019) (PubMed).

Details zu S1PR2

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Andere Bezeichnung: EDG-5 / S1P2

Hintergrund: The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: AGR16, EDG5, Endothelial differentiation G-protein coupled receptor 5, Gpcr13, H218, LPB2, S1P receptor 2, S1PR2, Sphingosine 1-phosphate receptor 2

Gen-ID: 9294

NCBI Accession: NP_004221

UniProt: O95136

Pathways: Synaptic Membrane