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Isocitrate Dehydrogenase Antikörper

IDH Reaktivität: Schwein WB, IF, IP, EIA, DB, ID, RIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN568270
  • Target Alle Isocitrate Dehydrogenase (IDH) Antikörper anzeigen
    Isocitrate Dehydrogenase (IDH)
    Reaktivität
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Schwein
    Wirt
    • 12
    • 1
    Kaninchen
    Klonalität
    • 13
    Polyklonal
    Konjugat
    • 8
    • 4
    • 1
    Dieser Isocitrate Dehydrogenase Antikörper ist unkonjugiert
    Applikation
    • 13
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Dot Blot (DB), Immunodiffusion (ID), Radioimmunoassay (RIA)
    Aufreinigung
    Ammonium Sulphate Precipitation and Ion Exchange Chromatography
    Immunogen
    Isocitrate Dehydrogenase isolated and purified from Porcine heart. Freund’s complete adjuvant is used in the first step of the immunization procedure.
    Isotyp
    IgG
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore by adding 1.0 mL sterile distilled water
    Konzentration
    10 mg/mL
    Buffer
    PBS, pH 7.2 without preservatives and foreign proteins
    Konservierungsmittel
    Without preservative
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody lyophilized at 2-8 °C and reconstituted at 2-8 °C for one week or (in aliquots) at -20 °C for longer. If a slight precipitation occurs upon storage, this should be removed by centrifugation.
  • Target
    Isocitrate Dehydrogenase (IDH)
    Andere Bezeichnung
    Isocitrate Dehydrogenase / IDH (IDH Produkte)
    Synonyme
    CG7176 antikoerper, CT22171 antikoerper, Dmel\\CG7176 antikoerper, IDH antikoerper, IDH-NADP antikoerper, Idh-NADP antikoerper, idh antikoerper, isocitrate dehydrogenase antikoerper, l(3)L3852 antikoerper, F20D21.16 antikoerper, F20D21_16 antikoerper, SMU.672 antikoerper, icd antikoerper, Isocitrate dehydrogenase antikoerper, isocitrate dehydrogenase antikoerper, isocitrate dehydrogenase, NADP-dependent antikoerper, Monomeric isocitrate dehydrogenase antikoerper, ankyrin repeat domain 26-like antikoerper, Idh antikoerper, ICDH antikoerper, idh antikoerper, icd antikoerper, SSO_RS10660 antikoerper, JK_RS08640 antikoerper, LOC618625 antikoerper
    Hintergrund
    Isocitrate dehydrogenase is an enzyme involved in the citric acid cycle. It is 416 amino acids long with a molecular weight of approximately 45 kDa. Isocitrate dehydrogenase enzymes catalyze the oxidative decarboxylation of isocitrate to produce alfa ketoglutarate. The human genome has 5 IDH genes coding for 3 IDH enzymes. The IDH1 and IDH2 require nicotinamide adeninedinucleotide phosphate (NADP) as co-substrate, whereas IDH3 require nicotinamide adenine dinucleotide (NAD). The IDH2 and 3 are localized in mitochondria and are actively involved in the citric acid cycle (TCA) for energy production in contrast, IDH1 is localized in cytoplasm and peroxisomes where it generates NADPH, reduced form of NADP for biosynthetic and other types of reaction. Since alfa KG and NADPH both are intermediately substrate for a number of cellular process, which allows the possibility of oncogenic or tumor suppressive activities of IDH1.Synonyms: Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, cytoplasmic Isocitrate dehydrogenase [NADP]
    Gen-ID
    9823
    UniProt
    P20304
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