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Isocitrate Dehydrogenase Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Isocitrate Dehydrogenase in WB, IF, IP, EIA, DB, ID und RIA. Er zeigt eine Reaktivität gegenüber Schwein.
Produktnummer ABIN568270

Kurzübersicht für Isocitrate Dehydrogenase Antikörper (ABIN568270)

Target

Alle Isocitrate Dehydrogenase (IDH) Antikörper anzeigen
Isocitrate Dehydrogenase (IDH)

Reaktivität

  • 7
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Schwein

Wirt

  • 12
  • 1
Kaninchen

Klonalität

  • 13
Polyklonal

Konjugat

  • 8
  • 4
  • 1
Dieser Isocitrate Dehydrogenase Antikörper ist unkonjugiert

Applikation

  • 13
  • 8
  • 7
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Dot Blot (DB), Immunodiffusion (ID), Radioimmunoassay (RIA)
  • Aufreinigung

    Ammonium Sulphate Precipitation and Ion Exchange Chromatography

    Immunogen

    Isocitrate Dehydrogenase isolated and purified from Porcine heart. Freund’s complete adjuvant is used in the first step of the immunization procedure.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    Restore by adding 1.0 mL sterile distilled water

    Konzentration

    10 mg/mL

    Buffer

    PBS, pH 7.2 without preservatives and foreign proteins

    Konservierungsmittel

    Without preservative

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody lyophilized at 2-8 °C and reconstituted at 2-8 °C for one week or (in aliquots) at -20 °C for longer. If a slight precipitation occurs upon storage, this should be removed by centrifugation.
  • Target

    Isocitrate Dehydrogenase (IDH)

    Andere Bezeichnung

    Isocitrate Dehydrogenase / IDH

    Hintergrund

    Isocitrate dehydrogenase is an enzyme involved in the citric acid cycle. It is 416 amino acids long with a molecular weight of approximately 45 kDa. Isocitrate dehydrogenase enzymes catalyze the oxidative decarboxylation of isocitrate to produce alfa ketoglutarate. The human genome has 5 IDH genes coding for 3 IDH enzymes. The IDH1 and IDH2 require nicotinamide adeninedinucleotide phosphate (NADP) as co-substrate, whereas IDH3 require nicotinamide adenine dinucleotide (NAD). The IDH2 and 3 are localized in mitochondria and are actively involved in the citric acid cycle (TCA) for energy production in contrast, IDH1 is localized in cytoplasm and peroxisomes where it generates NADPH, reduced form of NADP for biosynthetic and other types of reaction. Since alfa KG and NADPH both are intermediately substrate for a number of cellular process, which allows the possibility of oncogenic or tumor suppressive activities of IDH1.Synonyms: Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, cytoplasmic Isocitrate dehydrogenase [NADP]

    Gen-ID

    9823

    UniProt

    P20304
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