GUK1 Antikörper (Biotin)

Produktnummer ABIN568250

Der Kaninchen Polyklonal Anti-GUK1-Antikörper wurde für WB, IP, IF, DB, EIA, ID und RIA validiert. Er ist geeignet, GUK1 in Proben von Schwein zu detektieren.

Kurzübersicht für GUK1 Antikörper (Biotin) (ABIN568250)

Target: GUK1 (Guanylate Kinase 1 (GUK1))

Reaktivität: Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GUK1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Dot Blot (DB), Enzyme Immunoassay (EIA), Immunodiffusion (ID), Radioimmunoassay (RIA)

Produktdetails anti-GUK1 Antikörper (Biotin)

Produktmerkmale: Molar Ratio: Biotin/IgG = ~6.6

Aufreinigung: Ammonium Sulphate Precipitation and Ion Exchange Chromatography.

Immunogen: Guanylate kinase isolated and purified from Porcine brain. Freund’s complete adjuvant is used in the first step of the immunization procedure.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Restore by adding 1.0 mL sterile distilled water.

Konzentration: 10.0 mg/mL

Buffer: PBS, pH 7.2 without preservatives and foreign proteins.

Konservierungsmittel: Without preservative

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody lyophilized at 2-8 °C and reconstituted at 2-8 °C for one week or (in aliquots) at -20 °C for longer. If a slight precipitation occurs upon storage, this should be removed by centrifugation.

Details zu GUK1

Target: GUK1 (Guanylate Kinase 1 (GUK1))

Andere Bezeichnung: Guanylate Kinase / GUK1

Hintergrund: Guanylate kinase catalyzes the transfer of phosphate from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) or dGMP. This enzyme functions in the recovery of cGMP and is, therefore, thought to regulate the supply of guanine nucleotides to signal transduction pathways. The GUK2 and GUK3 isoforms are determined by separate loci. Brady et al. (1996) cloned human and mouse cDNAs of GUK1. They stated that the guanylate kinases are targets for cancer chemotherapy and are inhibited by the antitumor drug 6-thioguanine. They reported that the human gene codes for a protein of 197 amino acids with a mass of 21.7 kD. They found that the 1-kb message was ubiquitously expressed.Synonyms: GMK, GMP kinase

Gen-ID: 9823

UniProt: P31006

Pathways: Nucleotide Phosphorylation, ER-Nucleus Signaling, Ribonucleoside Biosynthetic Process