TCR alpha/beta Antikörper (APC)

Produktnummer ABIN567986

Es sind 5+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-TCR alpha/beta Antikörper wird verwendet zum Nachweis von TCR alpha/beta in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für TCR alpha/beta Antikörper (APC) (ABIN567986)

Target: TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TCR alpha/beta Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: IP26

Produktdetails anti-TCR alpha/beta Antikörper (APC)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Size-Exclusion Chromatography and adjusted for direct use

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE! This products is photosensitive and should be protected from light.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C.

Referenzen für anti-TCR alpha/beta Antikörper (APC) (ABIN567986)

Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: "NKp80 defines and stimulates a reactive subset of CD8 T cells." in: Blood, Vol. 113, Issue 2, pp. 358-69, (2009) (PubMed).

Sullivan, Coscoy: "Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein." in: Journal of virology, Vol. 82, Issue 2, pp. 602-8, (2008) (PubMed).

Chentouf, Ghannam, Bès, Troadec, Cérutti, Chardès et al.: "Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 1, pp. 409-20, (2007) (PubMed).

Ortonne, Huet, Gaudez, Marie-Cardine, Schiavon, Bagot, Musette, Bensussan: "Significance of circulating T-cell clones in Sezary syndrome." in: Blood, Vol. 107, Issue 10, pp. 4030-8, (2006) (PubMed).

Edwards, Grzyb, Dressler, Mansel, Zava, Sledge, McGuire: "Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer." in: Cancer research, Vol. 46, Issue 3, pp. 1306-17, (1986) (PubMed).

Details zu TCR alpha/beta

Target: TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

Andere Bezeichnung: T Cell Receptor / TCR alpha/beta

Hintergrund: The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.