POU2F1 Antikörper

Produktnummer ABIN567788

Der Maus Monoklonal anti-POU2F1 Antikörper wird verwendet zum Nachweis von POU2F1 in Proben von Human und Maus. Er wurde validiert für WB, IP und EMSA.

Kurzübersicht für POU2F1 Antikörper (ABIN567788)

Target: POU2F1 (POU Domain, Class 2, Transcription Factor 1 (POU2F1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser POU2F1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Electrophoretic Mobility-Shift Assay (EMSA)

Klon: YL15

Produktdetails anti-POU2F1 Antikörper

Spezifität: This antibody reacts with Oct-1 (90 kDa) on Western blotting. YL15 recognizes the POU-domain linker region of Human Oct-1.

Aufreinigung: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogen: Recombinant full-length Human Oct-1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu POU2F1

Target: POU2F1 (POU Domain, Class 2, Transcription Factor 1 (POU2F1))

Andere Bezeichnung: POU2F1 / OCT1

Hintergrund: Octamer transcrIPPtional factor 1 (Oct-1) is a 90 kDa transcrIPPtion factor that binds to the octamer motif ATTTGCAT. This ubiquitous regulatory element is most conspicuous in B cells, where it is found in every immunoglobulin (Ig) promoter and in most Ig enhancers. In addition, Oct-1 binding also activates the promoters of the genes for some small nuclear RNAs (snRNA) and for histone H2B. Oct-1 protein is expressed in multIPPle tissues although some Oct-1 isoforms appear to be tissue specific and the homologous Oct-2 appears to be restricted in expression to B-cells. At least in B-cells, the Oct proteins bind to DNA together with another protein transcrIPPtion factor, octamer binding factor-1 (OBF-1), to form a ternary complex.Synonyms: NF-A1, OTF1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, Otf-1, POU domain class 2 transcription factor 1

Gen-ID: 5451

NCBI Accession: NP_002688

UniProt: P14859