DBNL Antikörper (AA 201-300)

Produktnummer ABIN5675302

Der Kaninchen Polyklonal Anti-DBNL-Antikörper wurde für WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) und ICC validiert. Er ist geeignet, DBNL in Proben von Maus zu detektieren.

Kurzübersicht für DBNL Antikörper (AA 201-300) (ABIN5675302)

Target: DBNL (Drebrin-Like (DBNL))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DBNL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Produktdetails anti-DBNL Antikörper

Bindungsspezifität: AA 201-300

Kreuzreaktivität: Maus

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HIP55

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DBNL

Target: DBNL (Drebrin-Like (DBNL))

Andere Bezeichnung: HIP55

Hintergrund:

Synonyms: ABP1, Actin-binding protein 1, Cervical mucin associated protein, Cervical mucin-associated protein, Cervical SH3P7, CMAP, Dbnl, DBNL_HUMAN, Drebrin F, drebrin like, Drebrin like protein, Drebrin-F, Drebrin-like protein, HIP 55, HIP-55, HPK1 interacting protein of 55 kDa, HPK1-interacting protein of 55 kDa, SH3 domain containing protein 7, SH3 domain-containing protein 7, SH3P7, Src Homology 3 Domain Containing Protein, src homology 3 domain containing protein HIP

Background: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gen-ID: 28988

UniProt: Q9UJU6

Pathways: T-Zell Rezeptor Signalweg, Regulation of Actin Filament Polymerization