HIPK1 Antikörper (AA 1-100)

Produktnummer ABIN5675039

Dieses Anti-HIPK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HIPK1 in WB, ELISA, IF (cc), IF (p), IHC (p), ICC und IHC (fro). Geeignet für Human, Maus, Affe und Makake.

Kurzübersicht für HIPK1 Antikörper (AA 1-100) (ABIN5675039)

Target: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Reaktivität: Human, Maus, Affe, Makake

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIPK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-HIPK1 Antikörper

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Human, Makake, Affe, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HIPK1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu HIPK1

Target: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Andere Bezeichnung: HIPK1

Hintergrund:

Synonyms: Hipk 1, Hipk1, HIPK1_HUMAN, Homeodomain interacting protein kinase 1, Homeodomain interacting protein kinase 1 like protein, Homeodomain-interacting protein kinase 1, Myak, Nbak 2, Nbak2, Nuclear body associated kinase 2, Nuclear body associated kinase 2b

Background: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Gen-ID: 204851

UniProt: Q86Z02