MCU Antikörper (C-Term)

Produktnummer ABIN5673971

Dieser Anti-MCU Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von MCU in WB. Geeignet für Maus.

Kurzübersicht für MCU Antikörper (C-Term) (ABIN5673971)

Target: MCU (Mitochondrial Calcium Uniporter (MCU))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCU Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MCU Antikörper

Bindungsspezifität: C-Term

Sequenz: YPEARDRQYL LFFHKGAKKS RFDLEKYNQL KDAIAQAEMD LKRLRDPLQV

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of mouse CCDC109A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MCU

Target: MCU (Mitochondrial Calcium Uniporter (MCU))

Andere Bezeichnung: CCDC109A

Hintergrund: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity). Activity is regulated by MICU1 and MICU2 (By similarity). At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2, at higher Ca2+ levels MICU1 increases MCU activity (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.

Alias Symbols: Gm64, AV064928, C10orf42, Ccdc109a, 2010012O16Rik, D130073L02Rik

Protein Size: 201

Gen-ID: 215999

NCBI Accession: NM_001033259, NP_001028431

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis