NGEF Antikörper (C-Term)

Produktnummer ABIN5673216

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NGEF in WB. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für NGEF Antikörper (C-Term) (ABIN5673216)

Target: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NGEF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NGEF Antikörper

Bindungsspezifität: C-Term

Sequenz: GWFPSSMTEE ILNPKIRSQN LKECFRVHKM EDPQRSQNKD RRKLGSRNRQ

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of mouse NGEF

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NGEF

Target: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Andere Bezeichnung: NGEF

Hintergrund: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

Alias Symbols: Tims2, ephexin

Protein Size: 620

Gen-ID: 53972

NCBI Accession: NM_001111314, NP_001104784

Pathways: Neurotrophin Signalübertragung