EXOSC5 Antikörper (N-Term)

Produktnummer ABIN5672011

Der Kaninchen Polyklonal anti-EXOSC5 Antikörper (ABIN5672011) detektiert spezifisch EXOSC5 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen und Zebrafisch (Danio rerio).

Kurzübersicht für EXOSC5 Antikörper (N-Term) (ABIN5672011)

Target: EXOSC5 (Exosome Component 5 (EXOSC5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXOSC5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EXOSC5 Antikörper

Bindungsspezifität: N-Term

Sequenz: CSLRHFACEQ NLLSRPDGSA SFLQGDTSVL AGVYGPAEVK VSKEIFNKAT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against EXOS5. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human EXOS5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EXOSC5

Target: EXOSC5 (Exosome Component 5 (EXOSC5))

Andere Bezeichnung: EXOS5

Hintergrund: EXOS5 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation .

Alias Symbols: EXOSC5, CML28, RRP46,

Protein Interaction Partner: DOCK8, TRIM54, EXOSC1, FCHO1, IKZF3, EXOSC8, CALCOCO2, TNFAIP1, REL, KRT13, GOLGA2, BIRC2, UBC, rev, ZNF558, CDK5RAP1, EXOSC3, SRPK3, POLR2L, EXOSC10, PA2G4, LIPG, AICDA, DHRS2, EXOSC4, EXOSC2, PSIP1, EXOSC9, DIS3L, DIS3, CUL3, MEPCE, CDK9, SKIV2L2, EXOSC

Protein Size: 235

Gen-ID: 56915

NCBI Accession: NP_064543

UniProt: Q9NQT4

Pathways: SARS-CoV-2 Protein Interaktom