PRUNE2 Antikörper (C-Term)

Produktnummer ABIN5671800

Der Kaninchen Polyklonal anti-PRUNE2 Antikörper wird verwendet zum Nachweis von PRUNE2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für PRUNE2 Antikörper (C-Term) (ABIN5671800)

Target: PRUNE2 (Prune Homolog 2 (PRUNE2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRUNE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRUNE2 Antikörper

Bindungsspezifität: C-Term

Sequenz: LNDTHPRRIK LTAPNINLSL DQSEGSILSD DNLDSPDEID INVDELDTPD

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PRUNE2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PRUNE2

Target: PRUNE2 (Prune Homolog 2 (PRUNE2))

Andere Bezeichnung: PRUNE2

Hintergrund: The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants.

Alias Symbols: BMCC1, BNIPXL, C9orf65, KIAA0367

Protein Size: 352

Gen-ID: 158471

NCBI Accession: NM_001308047, NP_001294976