Rekombinanter CD4 Antikörper

Produktnummer ABIN5668250

Dieses Kaninchen Chimeric-Antikörper erkennt spezifisch CD4 in FACS, IP, IF, IHC (p), BP und Inh. Er zeigt eine Reaktivität gegenüber Human, Rhesusaffen und Cynomolgus.

Kurzübersicht für Rekombinanter CD4 Antikörper (ABIN5668250)

Target: CD4

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Rhesusaffen, Cynomolgus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Blocking Peptide (BP), Inhibition (Inh)

Klon: MT310

Produktdetails anti-CD4 Antikörper

Verwendungszweck: Anti-CD4 [MT310], Rabbit IgG, kappa

Spezifität: This antibody is specific for the CD4 extracellular domain D1 (binding the HIV-1 gp120-binding site).

Kreuzreaktivität: Cynomolgus, Rhesusaffen

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody strongly inhibits HIV-1 gp120-binding to CD4, which blocks HIV infectivity of CD4⁺ T lymphocytes, as well as the binding of MHCII, which results in the block of T-cell activation (possibly leading to anergy induction) (Qin et al., 2001, PMID: n/a). Additionally, antibody binding to CD4 leads to GM-CSF, TNF-α and IL-10 induction. (TNF-α induction only occurs after 20 hours.)

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD4

Target: CD4

Andere Bezeichnung: CD4

Hintergrund: Leu3/T3, T-cell differentiation antigen, Ly-4, L3T4, T-cell surface antigen T4/Leu-3

UniProt: P01730

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events