Rekombinanter CD4 (Clenoliximab Biosimilar) Antikörper

Produktnummer ABIN5668248

Der Rabbit Chimeric Anti--Antikörper wurde für BR, ELISA, FACS, IHC, SPR validiert. Er ist geeignet, in Proben von Human, Chimpanzee zu detektieren.

Kurzübersicht für Rekombinanter CD4 (Clenoliximab Biosimilar) Antikörper (ABIN5668248)

Target: CD4 (Clenoliximab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Schimpanse

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Unkonjugiert

Applikation: Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Surface Plasmon Resonance (SPR)

Klon: CE9-1

Produktdetails

Verwendungszweck: Anti-CD4 [CE9.1 (Clenoliximab)], Rabbit IgG, lambda

Spezifität: The antibody binds to human CD4 with a Kd of 1.0 nM and an ED50 of 0.2 μg/mL.

Kreuzreaktivität: Schimpanse

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG4 (primatized)

Aufreinigung: Protein A affinity purified

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: Domain 1 of human CD4.

Isotyp: IgG lambda

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 Molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.

Kommentare:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 (primatized) format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Antigendetails

Target: CD4 (Clenoliximab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: P55, T cell surface antign T4/Leu-3.

UniProt: P01730