Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper

Produktnummer ABIN5668227

Der Kaninchen Chimeric Anti-ErbB2/Her2 (Trastuzumab Biosimilar)-Antikörper wurde für FACS, ELISA und IHC validiert. Er ist geeignet, ErbB2/Her2 (Trastuzumab Biosimilar) in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper (ABIN5668227)

Target: ErbB2/Her2 (Trastuzumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Klon: 4D5-8

Produktdetails anti-ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper

Verwendungszweck: Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Rabbit IgG, kappa

Spezifität: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: A431 cells (human epidermoid carcinoma) (over)expressing EGFR.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu ErbB2/Her2 (Trastuzumab Biosimilar)

Target: ErbB2/Her2 (Trastuzumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR

UniProt: P04626