Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper

Produktnummer ABIN5668226

Dieses Human Monoklonal-Antikörper erkennt spezifisch ErbB2/Her2 (Trastuzumab Biosimilar) in FACS, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für Rekombinanter ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper (ABIN5668226)

Target: ErbB2/Her2 (Trastuzumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Klon: 4D5-8

Produktdetails anti-ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper

Verwendungszweck: Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Human IgG1, kappa

Spezifität: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: A431 cells (human epidermoid carcinoma) (over)expressing EGFR.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).

Kommentare:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Referenzen für anti-ErbB2/Her2 (Trastuzumab Biosimilar) Antikörper (ABIN5668226)

Maisel, Broka, Atwell, Bunch, Kupp, Singh, Mehta, Schroeder: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).

Details zu ErbB2/Her2 (Trastuzumab Biosimilar)

Target: ErbB2/Her2 (Trastuzumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR

UniProt: P04626