Rekombinanter RSV (Felvizumab Biosimilar) Antikörper

Produktnummer ABIN5668206

Der Human Monoklonal Anti-RSV (Felvizumab Biosimilar)-Antikörper wurde für ELISA und Func validiert. Er ist geeignet, RSV (Felvizumab Biosimilar) in Proben von Respiratory Syncytial Virus (RSV) zu detektieren.

Kurzübersicht für Rekombinanter RSV (Felvizumab Biosimilar) Antikörper (ABIN5668206)

Target: RSV (Felvizumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Respiratory Syncytial Virus (RSV)

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser RSV (Felvizumab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA, Functional Studies (Func)

Klon: RSHZ19

Produktdetails anti-RSV (Felvizumab Biosimilar) Antikörper

Verwendungszweck: Anti-RSV [RSHZ19 (Felvizumab)], Human IgG1, kappa

Spezifität: This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu RSV (Felvizumab Biosimilar)

Target: RSV (Felvizumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: SB 209763, respiratory syncytial virus