Rekombinanter TNF alpha (Adalimumab Biosimilar) Antikörper

Produktnummer ABIN5668145

Dieses Human Monoklonal-Antikörper erkennt spezifisch TNF alpha (Adalimumab Biosimilar) in ELISA, BR, IF und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für Rekombinanter TNF alpha (Adalimumab Biosimilar) Antikörper (ABIN5668145)

Target: TNF alpha (Adalimumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser TNF alpha (Adalimumab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon: D2E7

Produktdetails anti-TNF alpha (Adalimumab Biosimilar) Antikörper

Verwendungszweck: Anti-TNF alpha [D2E7 (Adalimumab)], Human IgG1, kappa

Spezifität: Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).

Kreuzreaktivität: Maus

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).

Kommentare:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Referenzen für anti-TNF alpha (Adalimumab Biosimilar) Antikörper (ABIN5668145)

Gupta, Flaskamp, Roentgen, Juergens, Armero-Gimenez, Albrecht, Hemmerich, Arfi, Neuser, Spiegel, Schillberg, Yeliseev, Song, Qiu, Williams, Finnern: "Scaling eukaryotic cell-free protein synthesis achieved with the versatile and high-yielding tobacco BY-2 cell lysate." in: Biotechnology and bioengineering, (2023) (PubMed).

Details zu TNF alpha (Adalimumab Biosimilar)

Target: TNF alpha (Adalimumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: Tumor necrosis factor alpha

UniProt: P01375