ALKBH7 Antikörper (AA 1-221)

Produktnummer ABIN5664063

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ALKBH7 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ALKBH7 Antikörper (AA 1-221) (ABIN5664063)

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ALKBH7 Antikörper

Bindungsspezifität: AA 1-221

Sequenz: MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ALKBH7

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Andere Bezeichnung: ALKBH7

Hintergrund: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7

Molekulargewicht: 24 kDa

Gen-ID: 84266

UniProt: Q9BT30