TRIB2 Antikörper (AA 254-343)
Kurzübersicht für TRIB2 Antikörper (AA 254-343) (ABIN565396)
Target
Alle TRIB2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 254-343
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Verwendungszweck
- Mouse monoclonal antibody raised against a partial recombinant TRIB2.
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Sequenz
- FHDIEPSSLF SKIRRGQFNI PETLSPKAKC LIRSILRREP SERLTSQEIL DHPWFSTDFS VSNSAYGAKE VSDQLVPDVN MEENLDPFFN
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Kreuzreaktivität
- Human
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Produktmerkmale
- Antibody Reactive Against Recombinant Protein.
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Immunogen
- TRIB2 (NP_067675, 254 a.a. ~ 343 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Isotyp
- IgG2b
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- In 1x PBS, pH 7.4
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Handhabung
- Aliquot to avoid repeated freezing and thawing.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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: "TRIB2 inhibits Wnt/?-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, ?-TrCP, COP1 and Smurf1, in liver cancer cells." in: FEBS letters, Vol. 588, Issue 23, pp. 4334-41, (2014) (PubMed).
: "Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ..." in: The Journal of biological chemistry, Vol. 288, Issue 47, pp. 33667-81, (2013) (PubMed).
: "Ubiquitin E3 ligase SCF(?-TRCP) regulates TRIB2 stability in liver cancer cells." in: Biochemical and biophysical research communications, Vol. 441, Issue 3, pp. 555-9, (2013) (PubMed).
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- TRIB2 (Tribbles Pseudokinase 2 (TRIB2))
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Andere Bezeichnung
- TRIB2
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Hintergrund
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Full Gene Name: tribbles homolog 2 (Drosophila)
Synonyms: C5FW,GS3955,TRB2 -
Gen-ID
- 28951
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NCBI Accession
- NM_021643
Target
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