PNP Antikörper (AA 161-189)

Produktnummer ABIN5647213

Der Kaninchen Polyklonal anti-PNP Antikörper wird verwendet zum Nachweis von PNP in Proben von Human, Maus und Ratte. Er wurde validiert für WB, FACS und IHC (p).

Kurzübersicht für PNP Antikörper (AA 161-189) (ABIN5647213)

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PNP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PNP Antikörper

Bindungsspezifität: AA 161-189

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids 161-189 (AMSDAYDRTMRQRALSTWKQMGEQRELQE-human) were used as the immunogen for the Purine nucleoside phosphorylase antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Purine nucleoside phosphorylase antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,Flow cytometry: 1-3 μg/10^6 cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Purine nucleoside phosphorylase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu PNP

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Andere Bezeichnung: PNP / Purine Nucleoside Phosphorylase

Hintergrund: The PNP gene encodes Purine nucleoside phosphorylase, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13. PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised T?lymphocyte function and neurologic dysfunction.

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus