MC3R Antikörper (AA 91-121)

Produktnummer ABIN5647192

Der Kaninchen Polyklonal anti-MC3R Antikörper wird verwendet zum Nachweis von MC3R in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC (p).

Kurzübersicht für MC3R Antikörper (AA 91-121) (ABIN5647192)

Target: MC3R (Melanocortin 3 Receptor (MC3R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC3R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MC3R Antikörper

Bindungsspezifität: AA 91-121

Verwendungszweck: MC3 Receptor Antibody / MC3R

Sequenz: NALETIMIAI VHSDYLTFED QFIQHMDNIF D

Aufreinigung: Antigen affinity

Immunogen: Amino acids 91-121 (NALETIMIAIVHSDYLTFEDQFIQHMDNIFD) from the human protein were used as the immunogen for the MC3 Receptor antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MC3 Receptor antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MC3 Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MC3R

Target: MC3R (Melanocortin 3 Receptor (MC3R))

Andere Bezeichnung: MC3 Receptor

Hintergrund: MC3 Receptor Antibody targets melanocortin 3 receptor, a G protein-coupled receptor encoded by the MC3R gene. Melanocortin 3 receptor is a member of the melanocortin receptor family, which includes five closely related receptors that mediate the biological effects of melanocortin peptides derived from proopiomelanocortin. MC3R is primarily involved in central regulation of energy balance, metabolic efficiency, and neuroendocrine signaling, with well-established roles in hypothalamic circuits that integrate nutritional status and hormonal cues.

Functionally, melanocortin 3 receptor is activated by endogenous ligands such as alpha-melanocyte-stimulating hormone and gamma-melanocyte-stimulating hormone. Upon ligand binding, MC3R predominantly couples to Gs proteins, leading to activation of adenylate cyclase and increased intracellular cyclic AMP levels. Through this signaling pathway, MC3R contributes to regulation of feeding behavior, energy expenditure, nutrient partitioning, and circadian rhythm integration. An MC3 Receptor Antibody supports studies focused on melanocortin signaling pathways, GPCR-mediated signal transduction, and neuroendocrine control of metabolism.

MC3R expression is most prominent within the central nervous system, particularly in hypothalamic regions involved in energy homeostasis, appetite regulation, and hormonal signaling. Expression has also been reported in peripheral tissues, including immune-related cells and metabolic organs, suggesting broader physiological roles beyond central appetite control alone. Subcellular localization is primarily associated with the plasma membrane, consistent with its function as a cell surface GPCR, although intracellular receptor pools involved in trafficking, recycling, and desensitization may be detected depending on cellular context and activation state.

At the molecular level, melanocortin 3 receptor displays the canonical seven-transmembrane domain architecture characteristic of class A GPCRs. Extracellular loops contribute to ligand recognition and binding specificity, while intracellular domains mediate interactions with G proteins and regulatory proteins involved in signal propagation and receptor desensitization. Receptor activity is influenced by post-translational modifications, accessory proteins, and cellular signaling environment, which together fine-tune MC3R responsiveness and downstream signaling output. These structural and regulatory features make MC3R a valuable model for studying GPCR biology and melanocortin system regulation.

From a disease relevance perspective, altered MC3R signaling has been investigated in the context of metabolic disorders, obesity, and disruptions in energy balance. Genetic variation within the MC3R gene has been associated with changes in body composition, feeding efficiency, and metabolic adaptation, highlighting the receptor's role in fine-tuning energy utilization rather than simply controlling food intake. In addition, MC3R has been studied for potential involvement in immune modulation and inflammatory responses, reflecting the expanding understanding of melanocortin signaling pathways beyond classical neuroendocrine functions. MC3 Receptor Antibody reagents support research applications examining GPCR signaling mechanisms, metabolic regulation, and melanocortin pathway involvement in health and disease, with NSJ Bioreagents providing reagents intended for research use.

UniProt: P41968

Pathways: cAMP Metabolic Process