CD41, CD61 Antikörper (PAC-1 epitope)

Produktnummer ABIN5633262

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD41, CD61 in FACS, IP und ICC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD41, CD61 Antikörper (PAC-1 epitope) (ABIN5633262)

Target: CD41, CD61 (CD41,CD61)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD41, CD61 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: PAC-1

Produktdetails anti-CD41, CD61 Antikörper

Bindungsspezifität: PAC-1 epitope

Verwendungszweck: Anti-Hu CD41/CD61 (PAC-1 epitope) Purified

Spezifität: The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Human platelets

Isotyp: IgM kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 2-4 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu CD41, CD61

Target: CD41, CD61 (CD41,CD61)

Andere Bezeichnung: CD41/CD61

Hintergrund: CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-Iib, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa