CASR Antikörper (N-Term)

Produktnummer ABIN5611429

Der Kaninchen Polyklonal anti-CASR Antikörper (ABIN5611429) detektiert spezifisch CASR in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für CASR Antikörper (N-Term) (ABIN5611429)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CASR Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to Calcium-Sensing Receptor CASR (CASR).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: CASR antibody was raised against a synthetic peptide from N-terminal of rat calcium sensing receptor Genename: CASR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 10 mM PBS, pH 7.4 containing BSA, sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Andere Bezeichnung: CaSR

Hintergrund: CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.Synonyms: Extracellular calcium-sensing receptor, GPRC2A, PCAR1, Parathyroid Cell calcium-sensing receptor

Gen-ID: 846

NCBI Accession: NP_000379

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis