ATRX Antikörper (AA 2311-2492)

Produktnummer ABIN5611354

Dieses Anti-ATRX-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ATRX in ELISA. Geeignet für Human.

Kurzübersicht für ATRX Antikörper (AA 2311-2492) (ABIN5611354)

Target: ATRX (helicase 2, X-linked (ATRX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 8B2H9

Produktdetails anti-ATRX Antikörper

Bindungsspezifität: AA 2311-2492

Verwendungszweck: ATRX Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human ATRX (AA: 2311-2492) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX

Hintergrund: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Molekulargewicht: 282.5 kDa

Gen-ID: 546