SLAMF7 Antikörper (AA 23-226)

Produktnummer ABIN5611285

Dieses Anti-SLAMF7-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SLAMF7 in ELISA, IHC und FACS. Geeignet für Human.

Kurzübersicht für SLAMF7 Antikörper (AA 23-226) (ABIN5611285)

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SLAMF7 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: 5G5A4

Produktdetails anti-SLAMF7 Antikörper

Bindungsspezifität: AA 23-226

Verwendungszweck: CD319 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD319 (AA: 23-226) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu SLAMF7

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Andere Bezeichnung: CD319

Hintergrund: "Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation."

Molekulargewicht: 37.4 kDa

Gen-ID: 57823

UniProt: Q9NQ25