SIRPA Antikörper (AA 235-373)

Produktnummer ABIN5611267

Dieses Anti-SIRPA-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SIRPA in FACS und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für SIRPA Antikörper (AA 235-373) (ABIN5611267)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIRPA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Klon: 2H7E2

Produktdetails anti-SIRPA Antikörper

Bindungsspezifität: AA 235-373

Verwendungszweck: CD172A Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD172A (AA: 235-373) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-SIRPA Antikörper (ABIN5611267)

Deuse, Hu, Agbor-Enoh, Jang, Alawi, Saygi, Gravina, Tediashvili, Nguyen, Liu, Valantine, Lanier, Schrepfer: "The SIRPα-CD47 immune checkpoint in NK cells." in: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: CD172A

Hintergrund: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Molekulargewicht: 55 kDa

UniProt: P78324