RORC Antikörper (pSer203)
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- Target Alle RORC Antikörper anzeigen
- RORC (RAR-Related Orphan Receptor C (RORC))
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Bindungsspezifität
- pSer203
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RORC Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Kreuzreaktivität (Details)
- A BLAST analysis was used to suggest reactivity with this protein with pongo abelii based on 100% homology for the immunogen sequence.
- Aufreinigung
- Anti-nuclear receptor ROR gamma pS203 is directed against mouse receptor ROR gamma phosphorylated at the serine 203 position. This product is an affinity purified antibody produced by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide to remove any unwanted reactivities.
- Immunogen
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Immunogen: Affinity purified Anti-receptor ROR gamma pS203 antibody was prepared from whole rabbit serum produced by repeated immunizations with an internal synthetic peptide phosphorylated at the serine 203 position of mouse receptor ROR gamma protein.
Immunogen Type: Peptide
- Isotyp
- IgG
- Top Product
- Discover our top product RORC Primärantikörper
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- Applikationshinweise
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Application Note: This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 61 kDa in size corresponding to receptor ROR gamma by western blotting in the appropriate cell lysate or extract.
Western Blot Dilution: 1 μg/mL
ELISA Dilution: 5 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.05 mg/mL
- Buffer
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Buffer: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
- Haltbarkeit
- 12 months
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- Target
- RORC (RAR-Related Orphan Receptor C (RORC))
- Andere Bezeichnung
- Nuclear receptor ROR gamma (RORC Produkte)
- Synonyme
- NR1F3 antikoerper, RORG antikoerper, RZR-GAMMA antikoerper, RZRG antikoerper, TOR antikoerper, Nr1f3 antikoerper, RORgamma antikoerper, Thor antikoerper, RAR related orphan receptor C antikoerper, RAR-related orphan receptor C antikoerper, RAR-related orphan receptor gamma antikoerper, RORC antikoerper, Rorc antikoerper
- Hintergrund
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Synonyms: Nr1f3, Rorg, Thor, RAR-related orphan receptor C, Nuclear receptor RZR-gamma, Thymus orphan receptor
Background: Anti-Nuclear receptor ROR gamma pS203 was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Nuclear receptor ROR gamma pS203 antibody detects mouse receptor ROR gamma phosphorylated at the serine 203 position. RAR-related orphan receptor gamma (ROR-γ) is a member of the nuclear receptor family of transcription factors. ROR-γ is a key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. ROR-γ regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. It is also involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism and is a negative regulator of adipocyte differentiation. It controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. Isoform 2, ROR-γt is essential for lymphoid organogenesis, in particular lymph nodes and Peyer's patches. ROR-γt also plays an important regulatory role in thymopoiesis, and in inhibiting apoptosis of undifferentiated T cells. Anti-nuclear receptor ROR gamma pS203 is ideal for researcher's interested in autoimmune diseases such as psoriasis and rheumatoid arthritis, circadian rhythms, and immune system disorders.
Gene Name: Rorc
- Gen-ID
- 19885
- NCBI Accession
- NP_001280663
- UniProt
- P51450
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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