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RORC Antikörper (pSer203)

RORC Reaktivität: Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5596977
  • Target Alle RORC Antikörper anzeigen
    RORC (RAR-Related Orphan Receptor C (RORC))
    Bindungsspezifität
    • 16
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer203
    Reaktivität
    • 97
    • 54
    • 23
    • 9
    • 8
    • 8
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 79
    • 17
    • 2
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 82
    • 19
    Polyklonal
    Konjugat
    • 53
    • 7
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser RORC Antikörper ist unkonjugiert
    Applikation
    • 80
    • 36
    • 24
    • 24
    • 15
    • 13
    • 11
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Kreuzreaktivität (Details)
    A BLAST analysis was used to suggest reactivity with this protein with pongo abelii based on 100% homology for the immunogen sequence.
    Aufreinigung
    Anti-nuclear receptor ROR gamma pS203 is directed against mouse receptor ROR gamma phosphorylated at the serine 203 position. This product is an affinity purified antibody produced by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide to remove any unwanted reactivities.
    Immunogen

    Immunogen: Affinity purified Anti-receptor ROR gamma pS203 antibody was prepared from whole rabbit serum produced by repeated immunizations with an internal synthetic peptide phosphorylated at the serine 203 position of mouse receptor ROR gamma protein.

    Immunogen Type: Peptide

    Isotyp
    IgG
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    Discover our top product RORC Primärantikörper
  • Applikationshinweise

    Application Note: This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 61 kDa in size corresponding to receptor ROR gamma by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1 μg/mL

    ELISA Dilution: 5 μg/mL

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.05 mg/mL
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
    Haltbarkeit
    12 months
  • Target
    RORC (RAR-Related Orphan Receptor C (RORC))
    Andere Bezeichnung
    Nuclear receptor ROR gamma (RORC Produkte)
    Synonyme
    NR1F3 antikoerper, RORG antikoerper, RZR-GAMMA antikoerper, RZRG antikoerper, TOR antikoerper, Nr1f3 antikoerper, RORgamma antikoerper, Thor antikoerper, RAR related orphan receptor C antikoerper, RAR-related orphan receptor C antikoerper, RAR-related orphan receptor gamma antikoerper, RORC antikoerper, Rorc antikoerper
    Hintergrund

    Synonyms: Nr1f3, Rorg, Thor, RAR-related orphan receptor C, Nuclear receptor RZR-gamma, Thymus orphan receptor

    Background: Anti-Nuclear receptor ROR gamma pS203 was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Nuclear receptor ROR gamma pS203 antibody detects mouse receptor ROR gamma phosphorylated at the serine 203 position. RAR-related orphan receptor gamma (ROR-γ) is a member of the nuclear receptor family of transcription factors. ROR-γ is a key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. ROR-γ regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. It is also involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism and is a negative regulator of adipocyte differentiation. It controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. Isoform 2, ROR-γt is essential for lymphoid organogenesis, in particular lymph nodes and Peyer's patches. ROR-γt also plays an important regulatory role in thymopoiesis, and in inhibiting apoptosis of undifferentiated T cells. Anti-nuclear receptor ROR gamma pS203 is ideal for researcher's interested in autoimmune diseases such as psoriasis and rheumatoid arthritis, circadian rhythms, and immune system disorders.

    Gene Name: Rorc

    Gen-ID
    19885
    NCBI Accession
    NP_001280663
    UniProt
    P51450
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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