IL1F10 Antikörper

Produktnummer ABIN5564279

Dieser Maus Monoklonal Antikörper erkennt spezifisch IL1F10 in ELISA und WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für IL1F10 Antikörper (ABIN5564279)

Target: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL1F10 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Klon: Nhat-1

Produktdetails anti-IL1F10 Antikörper

Spezifität: Recognizes human and mouse IL-38.

Kreuzreaktivität: Human, Maus

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human IL-38.

Isotyp: IgG2b

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu IL1F10

Target: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Andere Bezeichnung: IL-38

Hintergrund: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.