IL1RL1 Antikörper (Atto 647N)

Produktnummer ABIN5564243

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL1RL1 in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für IL1RL1 Antikörper (Atto 647N) (ABIN5564243)

Target: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1RL1 Antikörper ist konjugiert mit Atto 647N

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-IL1RL1 Antikörper (Atto 647N)

Spezifität: Recognizes endogenous ST2 by Flow Cytometry.

Kreuzreaktivität: Human

Immunogen: Recombinant human soluble ST2.

Anwendungsinformationen

Kommentare:

New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 647N shows red fluorescence (lambdaabs (max): 645nm, lambdaem (max): 669nm, epsilonmax: 120'000).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: +4°C
Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.

Haltbarkeit: 12 months

Details zu IL1RL1

Target: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Andere Bezeichnung: ST2

Hintergrund: ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.

UniProt: Q01638