Rekombinanter Netrin 1 Antikörper

Produktnummer ABIN5564235

Der Human Monoklonal anti-Netrin 1 Antikörper wird verwendet zum Nachweis von Netrin 1 in Proben von Human und Maus. Er wurde validiert für ELISA und Func.

Kurzübersicht für Rekombinanter Netrin 1 Antikörper (ABIN5564235)

Target: Netrin 1 (NTN1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser Netrin 1 Antikörper ist unkonjugiert

Applikation: ELISA, Functional Studies (Func)

Klon: 2F5

Produktdetails anti-Netrin 1 Antikörper

Verwendungszweck: anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)

Spezifität: Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

Keine Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

Produktmerkmale: Recombinant Antibody. Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles. Species cross-reactivity: Human, Mouse. Clone: 2F5. Isotype: Human IgG2lambda. Applications: ELISA, FUNC (Blocking). Host: HEK 293 cells. Liquid. In PBS containing 10 % glycerol. Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human Netrin-1.

Isotyp: IgG2 lambda

Anwendungsinformationen

Kommentare:

anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain.For negative control see Prod. No. AG-27B-0020PF.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu Netrin 1

Target: Netrin 1 (NTN1)

Andere Bezeichnung: Netrin-1

Hintergrund:

Alternate Names/Synonyms: NTN1, NP01-014

Product Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

UniProt: O95631

Pathways: Regulation of Cell Size