Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper

Produktnummer ABIN5564228

Dieses Human Monoklonal-Antikörper erkennt spezifisch CD40L (Ruplizumab Biosimilar) in FACS, WB und Func. Er zeigt eine Reaktivität gegenüber Human und Hund.

Kurzübersicht für Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper (ABIN5564228)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Hund

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser CD40L (Ruplizumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)

Klon: Hu5c8

Produktdetails anti-CD40L (Ruplizumab Biosimilar) Antikörper

Spezifität: Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.

Kreuzreaktivität: Hund, Human

Kreuzreaktivität (Details): Cross-reacts with canine CD40L.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.001EU/μg

Immunogen: Recombinant human CD40L.

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS.

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.

Haltbarkeit: 12 months

Details zu CD40L (Ruplizumab Biosimilar)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Andere Bezeichnung: CD40L (Ruplizumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

UniProt: P29965