ARF1 Antikörper

Produktnummer ABIN5557419

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch ARF1 in WB und IF (cc). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für ARF1 Antikörper (ABIN5557419)

Target: ARF1 (ADP-Ribosylation Factor 1 (ARF1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ARF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Klon: 1D4

Produktdetails anti-ARF1 Antikörper

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant human ARF1 protein, full length.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-2000
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C

Haltbarkeit: 12 months

Details zu ARF1

Target: ARF1 (ADP-Ribosylation Factor 1 (ARF1))

Andere Bezeichnung: ARF1

Hintergrund:

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Synonyms: ADP-ribosylation factor 1, ARF1

Gen-ID: 375

UniProt: P84077

Pathways: Transition Metal Ion Homeostasis, Inositol Metabolic Process