DOC2A Antikörper (AA 652-749)

Produktnummer ABIN5542714

Produktdetails anti-DOC2A Antikörper

Target: DOC2A (Double C2-Like Domains, alpha (DOC2A))

Bindungsspezifität: AA 652-749

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DOC2A Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: DOC2 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. Coli.

Klon: 2H7C4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu DOC2A

Target: DOC2A (Double C2-Like Domains, alpha (DOC2A))

Andere Bezeichnung: DOC2 (DOC2A Produkte)

Hintergrund: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 82.4 kDa

UniProt: P98082

Pathways: Synaptic Vesicle Exocytosis