DOC2A Antikörper (AA 652-749)
Kurzübersicht für DOC2A Antikörper (AA 652-749) (ABIN5542714)
Target
Alle DOC2A Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 652-749
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Verwendungszweck
- DOC2 Antibody
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Aufreinigung
- Purified antibody
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Immunogen
- Purified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. Coli.
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Isotyp
- IgG1
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Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- DOC2A (Double C2-Like Domains, alpha (DOC2A))
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Andere Bezeichnung
- DOC2
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Hintergrund
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This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Molekulargewicht
- 82.4 kDa
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UniProt
- P98082
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Pathways
- Synaptic Vesicle Exocytosis
Target
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