BIN1 Antikörper (AA 189-398)

Produktnummer ABIN5542281

Der Maus Monoklonal Anti-BIN1-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, BIN1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für BIN1 Antikörper (AA 189-398) (ABIN5542281)

Target: BIN1 (Bridging Integrator 1 (BIN1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon: 3B6A4

Produktdetails anti-BIN1 Antikörper

Bindungsspezifität: AA 189-398

Verwendungszweck: BIN1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human BIN1 (AA: 189-398) expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu BIN1

Target: BIN1 (Bridging Integrator 1 (BIN1))

Andere Bezeichnung: BIN1

Hintergrund: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Molekulargewicht: 64.7 kDa

Gen-ID: 274

UniProt: O00499