CD4 Antikörper (PE)

Produktnummer ABIN5541942

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-CD4 Antikörper wird verwendet zum Nachweis von CD4 in Proben von Pferd. Er wurde validiert für FACS.

Kurzübersicht für CD4 Antikörper (PE) (ABIN5541942)

Target: CD4

Reaktivität: Pferd

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD4 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: CVS4

Produktdetails anti-CD4 Antikörper (PE)

Spezifität: This anitbody CVS4 recognizes Equine CD4, a 58 kDa cell surface glycoprotein that is primarily expressed on a subpopulation of equine T lymphocytes and considered to be the equine homologue of human CD4. A study undertaken using Mouse anti Horse CD4, clone CVS4 to identify CD4 on several wild african equid species indicates that the CVS4 clone recognizes Somali wild ass (Equus asinus) but not Grévy's Zebra (E. grevyi) or Hartmann's Mountain Zebra (E. zebra).

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Equine thymocytes. Spleen cells from immunised mice were fused with cells of the X63-Ag 8.653 mouse myeloma cell line.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry : Use 10 μL of neat antibody to label 10 6 cells in 100 μL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Referenzen für anti-CD4 Antikörper (PE) (ABIN5541942)

De Schauwer, Piepers, Van de Walle, Demeyere, Hoogewijs, Govaere, Braeckmans, Van Soom, Meyer: "In search for cross-reactivity to immunophenotype equine mesenchymal stromal cells by multicolor flow cytometry." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 81, Issue 4, pp. 312-23, (2012) (PubMed).

Go, Zhang, Timoney, Cook, Horohov, Balasuriya: "Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3+ T lymphocytes and CD14+ monocytes." in: Journal of virology, Vol. 84, Issue 10, pp. 4898-911, (2010) (PubMed).

Details zu CD4

Target: CD4

Andere Bezeichnung: cd4

Hintergrund: CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes (helper/inducer T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.

UniProt: F6Y6X8

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events