CD4 Antikörper

Produktnummer ABIN5541941

Dieser Maus Monoklonal Antikörper detektiert spezifisch CD4 in FACS, IP und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Pferd. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für CD4 Antikörper (ABIN5541941)

Target: CD4

Reaktivität: Pferd

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: CVS4

Produktdetails anti-CD4 Antikörper

Spezifität: This anitbody reacts with T-helper cells, it recognises a 58 kDa cell surface glycoprotein that is primarily expressed on a subpopulation of equine T lymphocytes and considered to be the equine homologue of human CD4. Species: Equine (Horse).

Aufreinigung: Affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Equine thymocytes

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry : 1/25-1/200, use 10 μL of this working dilution to label 10e6 cells in 100 μL. Immunohistochemistry on Frozen sections. Immunoprecipitation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Containing 0.09 % Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Referenzen für anti-CD4 Antikörper (ABIN5541941)

Go, Zhang, Timoney, Cook, Horohov, Balasuriya: "Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3+ T lymphocytes and CD14+ monocytes." in: Journal of virology, Vol. 84, Issue 10, pp. 4898-911, (2010) (PubMed).

Goodman, Loregian, Perkins, Nugent, Buckles, Mercorelli, Kydd, Palù, Smith, Osterrieder, Davis-Poynter: "A point mutation in a herpesvirus polymerase determines neuropathogenicity." in: PLoS pathogens, Vol. 3, Issue 11, pp. e160, (2008) (PubMed).

Details zu CD4

Target: CD4

Andere Bezeichnung: cd4

Hintergrund: CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes (helper/inducer T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.

UniProt: F6Y6X8

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events