GZMK Antikörper

Produktnummer ABIN5541918

Der Maus Monoklonal anti-GZMK Antikörper wird verwendet zum Nachweis von GZMK in Proben von Human. Er wurde validiert für FACS, EIA und ELISA (Capture).

Kurzübersicht für GZMK Antikörper (ABIN5541918)

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GZMK Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Enzyme Immunoassay (EIA), ELISA (Capture)

Klon: GM26E7

Produktdetails anti-GZMK Antikörper

Spezifität: This antibody reacts to Granzyme K (GZMK). Species: Human.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Genetic immunisation with cDNA encoding human Granzyme K

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 μg/10 6 cells. ELISA: 1/200-1/400. ELISA (capture): Clone GM-6C3 as detection antibody. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu GZMK

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Andere Bezeichnung: granzyme k (gzmk)

Hintergrund: Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

UniProt: P49863